3-ethylisoxazole-5-carboxylic acid synthesis
- Product Name:3-ethylisoxazole-5-carboxylic acid
- CAS Number:14633-21-7
- Molecular formula:C6H7NO3
- Molecular Weight:141.12
90087-37-9
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$175.00/100mg
14633-21-7
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$154.00/500mg
Yield:14633-21-7 59.9%
Reaction Conditions:
with ethanol;sodium hydroxide at 30; for 1 h;
Steps:
265 EXAMPLE 265: Compound 521B: 3-ethyl-N-{[3-(4-{[(3S,4R)-3-fluoro-1-methylpiperidin-4- yl]amino}-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)-1,2,4-oxadiazol-5-yl]methyl}-1,2-oxazole-5- carboxamide
To ethyl 3-ethylisoxazole-5-carboxylate (80 mg, 473 μmol, 1 eq) in ethanol (1 mL) was added sodium hydroxide (3 M, 1 mL, 1 eq). The mixture was stirred at 30 °C for 1 h. The reaction mixture was quenched by adding 1N HCl to pH=7 at 0 °C, then concentrated in vacuo to give the carboxylic acid product (200 mg, 59.9% yield) as a yellow solid. LC-MS (ES+, m:z): 139.9 [(M+H)+].
References:
WO2021/231474,2021,A1 Location in patent:Paragraph 01126