3-fluoro-2-methoxy-benzamide synthesis

Yield:874830-59-8 90%

Reaction Conditions:

with 1H-imidazole;1,1'-bis-(diphenylphosphino)ferrocene;palladium diacetate;ammonium chloride;N-ethyl-N,N-diisopropylamine in 1,4-dioxane at 90; for 3 h;Sealed tube;

Steps:

General procedure for the synthesis of primary amides:

General procedure: To a stirred solution of aryl halide (Br/I) (1 mmol) in dry dioxane in a 25 mL sealed tube, was added Pd(OAc)2 (5 mol%), dppf (6 mol %), DIPEA (2 mmol), imidazole (0.25 mmol), ammonium chloride (2 mmol) and then Co2(CO)8 (0.3 mmol). The seal tube was closed immediately and stirred at 90 °C for 3h. After the reaction time the reaction mixture was cooled to room temperature. The reaction mixture was filtered through celite pad and washed with dioxane, the filtrate was concentrated under reduced pressure and the residue obtained was purified by column chromatography.

References:

Suresh;Baburajan, Poongavanam;Ahmed, Mansur [Tetrahedron Letters,2015,vol. 56,# 34,art. no. 46446,p. 4864 - 4867] Location in patent:supporting information