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3-FLUORO-4-IODO-QUINOLINE synthesis

2synthesis methods
396-31-6 Synthesis
3-FLUOROQUINOLINE

396-31-6
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3-FLUORO-4-IODO-QUINOLINE

213772-63-5
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Yield:213772-63-5 94%

Reaction Conditions:

Stage #1: 3-fluoroquinolinewith lithium diisopropyl amide in tetrahydrofuran at -78; for 4 h;Metallation;
Stage #2: with iodine in tetrahydrofuran at -78; for 2 h;Iodination;

References:

Arzel, Erwan;Rocca, Patrick;Marsais, Francis;Godard, Alain;Queguiner, Guy [Tetrahedron,1999,vol. 55,# 41,p. 12149 - 12156]

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