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939771-60-5

3-fluoro-5-iodophenol synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C
1.2: 1 h / Cooling with ice; Reflux
2.1: boron tribromide / dichloromethane / 13 h / -78 - 20 °C / Inert atmosphere

References:

Jorgensen, William L.;Bollini, Mariela;Thakur, Vinay V.;Domaoal, Robert A.;Spasov, Krasimir A.;Anderson, Karen S. [Journal of the American Chemical Society,2011,vol. 133,# 39,p. 15686 - 15696]