ChemicalBook CAS DataBase List 3-HYDROXYPHENYLUREA

3-HYDROXYPHENYLUREA synthesis

5synthesis methods

Product Name:3-HYDROXYPHENYLUREA
CAS Number:701-82-6
Molecular formula:C7H8N2O2
Molecular Weight:152.15

917-61-3 Synthesis

917-61-3
277 suppliers
$14.30/5g

591-27-5 Synthesis

591-27-5
531 suppliers
$11.00/10g

701-82-6
74 suppliers
$17.67/10gm:

Yield: 92%

Reaction Conditions:

with acetic acid in water at 20; for 1 h;

Steps:

4 General synthesis of arylurea analogues (4a-m)
General procedure: The procedure was performed adopting literature.46 To a solutionof ArNH2 (3, 5 mmol, dissolved in 10 mL acetic acid), wasadded aquatic solution of NaOCN (7.5 mmol, 7.5 mL). The mixturewas allowed to be stirred at room temperature for 1 h and thenconcentrated under reduced pressure. Afterwards, saturatedK2CO3 solution was added to adjust the pH to 7-8. A large scaleof precipitate was therefore formed, which was then filtered,washed with water for several times and then recrystallized fromMeOH - DCM

References:

Zhang, Mao;Liang, Yu-Ru;Li, Huan;Liu, Ming-Ming;Wang, Yang [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 24,p. 6623 - 6634]

590-28-3 Synthesis