3-Iodo-1-methyl-1H-pyrazole-4-carboxylicacid synthesis
- Product Name:3-Iodo-1-methyl-1H-pyrazole-4-carboxylicacid
- CAS Number:799835-40-8
- Molecular formula:C5H5IN2O2
- Molecular Weight:252.01
799835-39-5
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Yield:799835-40-8 94.5%
Reaction Conditions:
with water;sodium hydroxide in methanol at 50; for 1 h;
Steps:
7
To a solution of ethyl 3-iodo-1-methyl-lH-pyTazole-4-carboxylate (1 g,3.57 mmo1) in MeOH (15 mL) was added the solution of NaOH (714 mg, 17.85 mmo1) inH20 (2 mL), the mixture was stirred at 50 oc for lh. The reaction mixture was concentratedto remove MeOH, then diluted with water (30 mL), acidified with 1N HCl to pH ~ 3, theprecipitate was formed, the solid was filtered and dried in vacuum. The residue was used into the next step without further purification. Compound 17A (850 mg, yield: 94.5%) aswhite solid was obtained. 1H NMR (400MHz, DMSO-d6) 5 12.45 (s, 1H), 8.31 - 8.08 (m,lH), 3.96- 3.76 (m, 3H).
References:
WO2019/190885,2019,A1 Location in patent:Paragraph 0351
21230-43-3
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