3-iodo-4-methyl-5-nitrobenzoic acid synthesis
- Product Name:3-iodo-4-methyl-5-nitrobenzoic acid
- CAS Number:21312-29-8
- Molecular formula:C8H6INO4
- Molecular Weight:307.04
96-98-0
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Yield:21312-29-8 95%
Reaction Conditions:
with sulfuric acid;sulfur trioxide;iodine at 85;
Steps:
3.1
Step 1 3-Iodo-4-methyl-5-nitro-benzoic acidTo a mixture of iodine (19.6 g, 77.3 mmol) in fuming sulfuric acid (35 mL) was added 4-methyl-3-nitro-benzoic acid (10.0 g, 55.2 mmol). The mixture was stirred at 85° C. over night, then cooled to room temperature and poured over ice. The mixture was partitioned between ethyl acetate and aqueous sodium bisulfite, and the organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to give 16.06 g (95%) of 3-iodo-4-methyl-5-nitro-benzoic acid.
References:
US2010/324070,2010,A1 Location in patent:Page/Page column 20
54591-62-7
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21312-29-8
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