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ChemicalBook CAS DataBase List 3-iodo-5-Methylbenzonitrile
52107-71-8

3-iodo-5-Methylbenzonitrile synthesis

4synthesis methods
186551-97-3 Synthesis
3-AMino-5-Methyl-benzonitrile

186551-97-3
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Yield:52107-71-8 76 %

Reaction Conditions:

Stage #1: 3-amino-5-methylbenzonitrilewith hydrogenchloride;sodium nitrite in water;acetone at 0;
Stage #2: with potassium iodide in water;acetone at 0;Reflux;

References:

Bidesi, Natasha;Shalgunov, Vladimir;Battisti, Umberto Maria;Hvass, Lars;J?rgensen, Jesper Tranekj?r;Poulie, Christian B. M.;Jensen, Andreas I.;Kjaer, Andreas;Herth, Matthias M. [Journal of labelled compounds and radiopharmaceuticals,2023,vol. 66,# 1,p. 22 - 30]