ChemicalBook CAS DataBase List 3-Methoxybenzylamine

3-Methoxybenzylamine synthesis

13synthesis methods

Product Name:3-Methoxybenzylamine
CAS Number:5071-96-5
Molecular formula:C8H11NO
Molecular Weight:137.18

1527-89-5
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$6.00/5g

5071-96-5
256 suppliers
$5.00/1g

Yield:5071-96-5 95%

Reaction Conditions:

with ammonia borane in methanol at 50; for 12 h;Inert atmosphere;

Steps:

8

Add PdNPore (2.7mg, 5mol%) catalyst into the mesoporous reactorAnd ammonia borane complex (30.86mg, 1mmol),Add methanol (3mL) under nitrogen,Add the substrate m-methoxybenzonitrile (58.5mg, 0.5mmol),Put it in an oil bath and react at 50 for 12h,After separation and purification by column chromatography (silica gel, 200-300 mesh; the developing solvent is ethyl acetate: methanol = 2:1),Obtained 65.4 mg of m-methoxybenzylamine,The yield was 95%.

References:

CN112851521,2021,A Location in patent:Paragraph 0077-0080