3-METHYLPHENYL CHLOROFORMATE synthesis
- Product Name:3-METHYLPHENYL CHLOROFORMATE
- CAS Number:29430-39-5
- Molecular formula:C8H7ClO2
- Molecular Weight:170.59
32315-10-9
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Yield:-
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in tetrahydrofuran;N,N-dimethyl-formamide at 20; for 2 h;
Steps:
4.5. A general procedure for acylation of carbolines (method E)
General procedure: To a mixture of phosgene (or its analog, such as triphosgene, ~1equiv) and base (such as NEt3, DIEA, ~2-3 equiv.) in solvent (such asDCM, THF) at rt was added an alcohol (~1 equiv.). The mixture was stirred at rt for 1h to generate the chloroformate. To the mixture wasadded an amine 7 (~1-2 equiv, neat or a solution in DMF). The mixturestirred at rt for several hours before being quenched with methanol. Themixture was concentrated and purified by chromatography to providethe final compound.
References:
Baiazitov, Ramil Y.;Qi, Hongyan;Arasu, Tamil;Lennox, William;Cao, Liangxian;Weetall, Marla;Furia, Bansri;Zhuo, Jin;Choi, Soongyu;Kim, Min Jung;Sheedy, Josephine;Davis, Thomas;Moon, Young-Choon [European Journal of Medicinal Chemistry,2022,vol. 244,art. no. 114826]
