3-oxo-2-pentylcyclopentaneacetic acid synthesis
- Product Name:3-oxo-2-pentylcyclopentaneacetic acid
- CAS Number:3572-64-3
- Molecular formula:C12H20O3
- Molecular Weight:212.29
24851-98-7
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3572-64-3
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Yield: 99%
Reaction Conditions:
Stage #1:methyl 3-oxo-2-pentylcyclopentaneacetate with sodium hydroxide in methanol at 20; for 24 h;
Stage #2: with hydrogenchloride in methanol;water; pH=~ 1
Steps:
1.1
Sodium hydroxide pellets (82.6g) were dissolved in methanol (425 ml) with stirring. This solution was added to a stirred solution of methyldihydrojasmonate (425g)(obtained from F. D. Copeland) in methanol (425 ml). The reaction mixture was stirred at room temperature for 24 hours. After this time TLC analysis (10:90 ethylacetate EtOAc):Hexane) confirmed that all starting material had been consumed. Aqueous 1M hydrochloric acid solution was added slowly until the pH of the reaction mixture was ~1. The aqueous/methanol solution was extracted with ethyl acetate (4 x 150 ml) and the combined organic extracts were dried (MgS04) and evaporated under vacuum to give the dihydrojasmonic acid as a pale yellow oil (397.0g,>99%). The structure was confirmed using ¹H and ¹3C NMR.
References:
BIOFUTURES PI LIMITED WO2005/102047, 2005, A1 Location in patent:Page/Page column 14
51806-23-6
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24851-98-7
403 suppliers
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3572-64-3
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$43.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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3572-64-3
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110-53-2
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3572-64-3
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1000210-73-0
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3572-64-3
51 suppliers
$43.00/100mg