3-(Propan-2-yl)azetidin-3-ol hydrochloride synthesis

Yield:848192-94-9 98%

Reaction Conditions:

with hydrogenchloride;hydrogen;palladium dihydroxide;palladium on carbon in methanol;water; under 2585.81 Torr;

Steps:

Intermediate 26

3-isopropylazetidin-3-ol. To a solution of 1-benzhydryl-3-isopropylazetidin-3-ol (80 mg, 0.284 mmol) in MeOH (10 mL), Pd(OH)2 with 20% Pd on carbon (80 mg) and 1N HCl solution (0.284 mL, 0.284 mmol) were added. The reaction mixture was shaken under a hydrogenator at 50 psi for overnight. The catalyst was filtered through celite and washed with methanol. The filtrate was concentrated and dried under vacuum. The residue was then washed with hexanes. The organic layer was decanted and a white solid was obtained as final product as hydrochloride salt. (42 mg, 98% yield). MS m/z 116(MH+).

References:

US2007/275930,2007,A1 Location in patent:Page/Page column 26