3-Pyridinecarbonitrile,6-(methylthio)-(9CI) synthesis
- Product Name:3-Pyridinecarbonitrile,6-(methylthio)-(9CI)
- CAS Number:408350-80-1
- Molecular formula:C7H6N2S
- Molecular Weight:150.2
33252-28-7
442 suppliers
$6.00/1g
5188-07-8
287 suppliers
$13.00/5g
408350-80-1
13 suppliers
inquiry
Yield:408350-80-1 100%
Reaction Conditions:
in tetrahydrofuran; for 9 h;Heating / reflux;
Steps:
47 Reference Example 47
Reference Example 47 5-Cyano-2-methylthiopyridine 2-Chloro-5-cyanopyridine (2.10 g, 15.1 mmol) and sodium thiomethoxide (1.16 g, 16.5 mmol) were added to THF (30 ml).. The reaction mixture was refluxed for 9 hrs and combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated to give the titled compound (2.26 g, 100%) as pale yellow crystals. IR (KBr): 2229, 1585, 1533, 1460, 1363, 1113, 912, 742 cm-1.1H-NMR (CDCl3) δ: 2.59 (3H, s), 7.24-7.27 (1H, m), 7.64-7.67 (1H, m), 8.66-8.67 (1H, m).
References:
EP1424336,2004,A1 Location in patent:Page 126
867-44-7
378 suppliers
$5.00/10g
139585-70-9
309 suppliers
$10.00/1g
408350-80-1
13 suppliers
inquiry
27885-58-1
39 suppliers
inquiry
408350-80-1
13 suppliers
inquiry