(3-PYRROLIDIN-1-YLPHENYL)METHYLAMINE synthesis
- Product Name:(3-PYRROLIDIN-1-YLPHENYL)METHYLAMINE
- CAS Number:175696-70-5
- Molecular formula:C11H16N2
- Molecular Weight:176.26
828242-06-4
2 suppliers
inquiry
175696-70-5
32 suppliers
$45.00/10mg
Yield:175696-70-5 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 2 h;
Steps:
11 Preparation of 3 and 4-alkylaminobenzylamine derivatives
General procedure: To a stirred solution of carbamate (1 equiv.) in dry DCM TFA (10 equiv.) was added. The reaction mixture was stirred at room temperature for 2h. The mixture was quenched with a saturated aqueous solution of sodium bicarbonate and the product was extracted with DCM. The organic layers were dried over Na2S04, filtered and concentrated under vacuum to provide the expected compound which was used without further purificationThe following compounds are examples illustrating this procedure:.; 3-pyrrolidin-1 -ylphenyl)methanamine was prepared from te/t-butyl N-[(3- pyrrolidin-1 -ylphenyl)methyl]carbamate (203 mg, 0.74 mmol). Yield: 130 mg (100%) of the title compound as a brown oil.
References:
WO2017/191297,2017,A1 Location in patent:Page/Page column 134; 135
175696-73-8
27 suppliers
inquiry
175696-70-5
32 suppliers
$45.00/10mg
2237-30-1
276 suppliers
$13.00/25g
175696-70-5
32 suppliers
$45.00/10mg
766-84-7
274 suppliers
$9.00/10g
175696-70-5
32 suppliers
$45.00/10mg
263351-43-5
31 suppliers
inquiry
175696-70-5
32 suppliers
$45.00/10mg