3-Pyrrolidinecarboxamide, 5-oxo-1-(phenylmethyl)- synthesis

Yield:-

Reaction Conditions:

with ammonia in methanol;

Steps:

4.1 Step 1

Step 1 Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (50 g, 0.21 mol) was stirred in a solution of ammonia in methanol (7 M, 400 mL, 2.8 mol). After 2 days, the solution was concentrated with heating (50° C.) to about 300 mL at which point all solids remained dissolved. The reaction was then allowed to cool down and the resulting solid was filtered, washed with ether and dried to give 1-benzyl-5-oxo-pyrrolidine-3-carboxylic acid amide as colorless crystals (40 g).

References:

US6166015,2000,A