3-Trifluoromethyl-a-oxo-benzenepropanoic acid synthesis

4synthesis methods

Product Name:3-Trifluoromethyl-a-oxo-benzenepropanoic acid
CAS Number:120658-70-0
Molecular formula:C10H7F3O3
Molecular Weight:232.16

5-(m-(Trifluoromethyl)benzylidene)hydantoin

76605-42-0
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3-Trifluoromethyl-a-oxo-benzenepropanoic acid

120658-70-0
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Yield:120658-70-0 75.1%

Reaction Conditions:

with water;sodium hydroxide at 105; for 2 h;

Steps:

2 Preparation of the compound 2-oxo-m-trifluoromethyl-3-phenylpropionic acid

Add 43 g of 5-(3-trifluoromethylbenzylidene)imidazoline-2,4-dione pale yellow solid to a 500mL reaction flask,200mL of sodium hydroxide solution with a concentration of 5% by mass, heated to reflux at 105°C for 2h,After the reaction is complete, stop heating, cool to room temperature, adjust the pH of the solution to 3 with hydrochloric acid with a mass percentage concentration of 10% under ice bath conditions, and stir and crystallize for 9 hours;After suction filtration, the filter cake was washed with a small amount of ethanol and dried under vacuum at 50°C to obtain 30.8 g of the compound 2-oxo-m-trifluoromethyl-3-phenylpropionic acid, with a yield of 75.1%.

References:

CN111704577,2020,A Location in patent:Paragraph 0029; 0039-0040

2-Propenoic acid, 2-(acetylamino)-3-[3-(trifluoromethyl)phenyl]-

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References

454-89-7 Synthesis

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$14.00/25g

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References

5(4H)-Oxazolone, 2-methyl-4-[[3-(trifluoromethyl)phenyl]methylene]-, (4Z)-

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References