ChemicalBook CAS DataBase List 3-(TRIFLUOROMETHYL)BENZOPHENONE

3-(TRIFLUOROMETHYL)BENZOPHENONE synthesis

10synthesis methods

Product Name:3-(TRIFLUOROMETHYL)BENZOPHENONE
CAS Number:728-81-4
Molecular formula:C14H9F3O
Molecular Weight:250.22

728-80-3 Synthesis

728-80-3
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$10.00/1g

728-81-4
68 suppliers
$15.00/5g

Yield: 99%

Reaction Conditions:

with N-Bromosuccinimide;potassium acetate in dichloromethane;water at 20; for 10 h;Green chemistry;

Steps:

General Procedure for the Oxidative Reaction
General procedure: A solution of diphenylmethanol (1 mmol), NBS (1.3equiv.), KOAc (1.5 equiv.) H2O (1.5 mL), and CH2Cl2 (0.5mL) was magnetically stirred in 25 mL flask at room temperaturefor 10 h. The reaction mixture was added into water(10 mL), and extracted with EtOAc (3 × 10 mL). The combinedEtOAc extracts were dried over anhydrous MgSO4,filtrated, and then the solvent was removed under reducedpressure. The residue was purified by the flash columnchromatography on silica gel with PE or PE/EtOAc as theeluent to obtain the desired products. The oxidation productswere identified by GC-MS and 1H NMR.

References:

Wu, Jianglong;Liu, Yan;Liu, Ping;Gu, Chengzhi [Letters in Organic Chemistry,2017,vol. 14,# 4,p. 254 - 260]