5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid synthesis

1synthesis methods

Product Name:5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS Number:312922-11-5
Molecular formula:C15H10F3N3O2
Molecular Weight:321.25

4,4,4-Trifluoro-1-(p-tolyl)-1,3-butanedione

720-94-5
326 suppliers
$17.00/5g

5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

312922-11-5
9 suppliers
$252.00/500mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: acetic acid / 0.3 h / Microwave irradiation
2.1: sodium hydroxide / ethanol; water / 4 h / 65 °C
2.2: 20 °C / pH 1

References:

Mulakayala, Naveen;Reddy, Upendar;Chaitanya;Hussain, Manzoor;Kumar, Chitta Suresh;Golla, Narayanaswamy [Journal of the Korean Chemical Society,2011,vol. 55,# 4,p. 719 - 722]