Methyl 4-(3-hydroxy-4-methylisoxazol-5-yl)piperidine-1-carboxylate synthesis
- Product Name:Methyl 4-(3-hydroxy-4-methylisoxazol-5-yl)piperidine-1-carboxylate
- CAS Number:321904-86-3
- Molecular formula:C11H16N2O4
- Molecular Weight:240.26
321904-75-0
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321904-86-3
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Yield:321904-86-3 57%
Reaction Conditions:
Stage #1: ethyl 3-(1-methoxycarbonyl-4-piperidyl)-2-methyl-3-oxopropionatewith sodium hydroxide;hydroxylamine hydrochloride in methanol at -30; for 2 h;
Stage #2: with hydrogenchloride in methanol at 80; for 2 h;Further stages.;
References:
Fr?lund, Bente;J?rgensen, Anne T.;Tagmose, Lena;Stensb?l, Tine B.;Vestergaard, Henrik T.;Engblom, Christine;Kristiansen, Uffe;Sanchez, Connie;Krogsgaard-Larsen, Povl;Liljefors, Tommy [Journal of Medicinal Chemistry,2002,vol. 45,# 12,p. 2454 - 2468]
167414-69-9
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321904-86-3
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197585-43-6
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321904-86-3
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197585-42-5
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$75.00/100mg
321904-86-3
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