2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid synthesis
- Product Name:2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid
- CAS Number:32445-89-9
- Molecular formula:C11H11F3O2
- Molecular Weight:232.2
32445-87-7
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32445-89-9
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Yield:32445-89-9 81%
Steps:
119.2 Step 2.
Step 2.
Synthesis of 2-methyl-2-(4-(trifluoromethyl)phenyl)propionic acid
A solution of 2-methyl-2-(4-(trifluoromethyl)phenyl)propionitrile (400 mg, 1.88 mmol) and NaOH (10 M, 1 mL) in EtOH (5 mL) was refluxed at 100°C overnight.
After the mixture was cooled to room temperature, EtOAc (15 mL) was added.
The two layers were separated, and the organic solution was extracted with water (10 mL*3).
The combined aqueous layer was acidified with concentrated hydrochloric acid to pH=2-3. HCl solution.
Then the aqueous layer was extracted with EtOAc (20 mL*3).
The combined organic layer was washed with brine (20 mL*2), dried over anhydrous Na2SO4 and concentrated in vacuo to obtain the desired compound (390 mg, yield 81%) as a white solid. 1HNMR (400 MHz, DMSO-d6): δ 12.56 (s, 1H), 7.70 (d, J= 8.0 Hz, 2H), 7.58 (d, J= 8.0 Hz, 2H), 1.51 (s, 6H).
References:
EP3960736,2022,A1
![Methyl 2-methyl-2-[4-(trifluoromethyl)phenyl]propanoate](/CAS/20200331/GIF/CB45299889.gif)
476429-18-2
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32445-89-9
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32857-62-8
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721-63-1
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32445-89-9
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2338-75-2
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32445-89-9
36 suppliers
$125.00/0.5g