6-METHYL-2-OXO-1,2-DIHYDRO-4-QUINOLINECARBOXYLIC ACID synthesis
- Product Name:6-METHYL-2-OXO-1,2-DIHYDRO-4-QUINOLINECARBOXYLIC ACID
- CAS Number:33274-47-4
- Molecular formula:C11H9NO3
- Molecular Weight:203.19
Yield:33274-47-4 70%
Reaction Conditions:
with acetic acid for 12 h;Inert atmosphere;Reflux;
Steps:
2-Oxo-1, 2-dihydroquinoline-4-carboxylic acid (12a)10
General procedure: A mixture of isatin (1.0 g, 6:8 mmol), and malonic acid (1.07 g, 10.3 mmol) in acetic acid (8 mL) was placed in an round bottomed flask and then refluxed for 12 h. Precipitated solid was filtered, washed with acetone, ether, and dried to give the desired product in 80 % yield.
References:
Dulla, Balakrishna;Wan, Baojie;Franzblau, Scott G.;Kapavarapu, Ravikumar;Reiser, Oliver;Iqbal, Javed;Pal, Manojit [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 14,p. 4629 - 4635] Location in patent:supporting information; experimental part
118726-65-1
1 suppliers
inquiry
33274-47-4
22 suppliers
$70.00/1g