2-(2,4-DICHLOROPHENYL)-2-[6-(PHENYLSULFANYL)-3-PYRIDAZINYL]ACETONITRILE synthesis

Yield:-

Reaction Conditions:

with sulfuric acid at 100;

References:

Duffy, John P.;Harrington, Edmund M.;Salituro, Francesco G.;Cochran, John E.;Green, Jeremy;Gao, Huai;Bemis, Guy W.;Evindar, Ghotas;Galullo, Vincent P.;Ford, Pamella J.;Germann, Ursula A.;Wilson, Keith P.;Bellon, Steven F.;Chen, Guanging;Taslimi, Paul;Jones, Peter;Huang, Cassey;Pazhanisamy;Wang, Yow-Ming;Murcko, Mark A.;Su, Michael S.S. [ACS Medicinal Chemistry Letters,2011,vol. 2,# 10,p. 758 - 763] Location in patent:supporting information; experimental part