CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS synthesis

Yield:3396-20-1 82%

Reaction Conditions:

with triethylsilane in tetrahydrofuran; for 6 h;Reflux;

Steps:

3

Dimethyl 1,2-cyclobutenedicarboxylate (60 g) was added to THF (1 L), and then triethylsilane (90 g) was slowly added.After the reaction was refluxed for 6 hours, it was cooled to room temperature.The reaction was quenched by the addition of HCl solution (1 N).After most of the THF was removed by rotary distillation, ethyl acetate was added (200 ml of X3).After combining the extracts,Dry distillation productMethyl 1,2-cyclobutanedicarboxylate(48g, yield 82%)

References:

CN108658762,2018,A Location in patent:Paragraph 0039; 0042