1-ethenyl-2-oxabicyclo[2.2.2]octane-4-carboxylic acid synthesis
- Product Name:1-ethenyl-2-oxabicyclo[2.2.2]octane-4-carboxylic acid
- CAS Number:340023-04-3
- Molecular formula:C10H14O3
- Molecular Weight:182.22
![1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol](/CAS/GIF/1256546-72-1.gif)
1256546-72-1
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340023-04-3
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Yield:-
Steps:
Multi-step reaction with 7 steps
1: pyridine / 20 °C
2: hydrogenchloride / tetrahydrofuran / 5 h / Reflux
3: tetrahydrofuran / 5.25 h / -78 °C
4: sodium hydride / 1,2-dimethoxyethane; mineral oil / 2.5 h / Reflux
5: N,N-dimethyl-formamide / 100 °C
6: potassium carbonate / methanol; water / 2 h / 20 °C / Cooling
7: pyridinium dichromate / N,N-dimethyl-formamide / 3.5 h / 25 - 40 °C
References:
Singh, Sheo B.;Kaelin, David E.;Wu, Jin;Miesel, Lynn;Tan, Christopher M.;Meinke, Peter T.;Olsen, David;Lagrutta, Armando;Bradley, Prudence;Lu, Jun;Patel, Sangita;Rickert, Keith W.;Smith, Robert F.;Soisson, Stephen;Wei, Changqing;Fukuda, Hideyuki;Kishii, Ryuta;Takei, Masaya;Fukuda, Yasumichi [ACS Medicinal Chemistry Letters,2014,vol. 5,# 5,p. 609 - 614]
![{1-ethenyl-2-oxabicyclo[2.2.2]octan-4-yl}methanol](/CAS/20180702/GIF/340023-03-2.gif)
340023-03-2
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340023-04-3
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57899-62-4
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340023-04-3
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55704-60-4
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340023-04-3
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![diethyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate](/CAS/GIF/1256546-71-0.gif)
1256546-71-0
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340023-04-3
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