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343322-66-7

5-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID synthesis

1synthesis methods
5-Methyl-2-(4-trifluoromethylphenyl)-thiazole-4-carboxylic acid ethyl ester

343322-65-6
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5-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID

343322-66-7
16 suppliers
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Yield:343322-66-7 74%

Reaction Conditions:

with sodium hydroxide in ethanol at 85; for 1.5 h;

References:

Sierra, Michael L.;Beneton, Véronique;Boullay, Anne-Bénédict;Boyer, Thierry;Brewster, Andrew G.;Donche, Frédéric;Forest, Marie-Claire;Fouchet, Marie-Hélène;Gellibert, Fran?oise J.;Grillot, Didier A.;Lambert, Millard H.;Laroze, Alain;Le Grumelec, Christelle;Linget, Jean Michel;Montana, Valerie G.;Nguyen, Van-Loc;Nicodème, Edwige;Patel, Vipul;Penfornis, Annie;Pineau, Olivier;Pohin, Danig;Potvain, Florent;Poulain, Géraldine;Ruault, Cécile Bertho;Saunders, Michael;Toum, Jér?me;Xu, H. Eric;Xu, Robert X.;Pianetti, Pascal M. [Journal of Medicinal Chemistry,2007,vol. 50,# 4,p. 685 - 695]