1H-Isoindole-1,3(2H)-dione, 2-(3,3,3-trifluoropropyl)- synthesis
- Product Name:1H-Isoindole-1,3(2H)-dione, 2-(3,3,3-trifluoropropyl)-
- CAS Number:347190-33-4
- Molecular formula:C11H8F3NO2
- Molecular Weight:243.18
574011-88-4
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347190-33-4
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Yield:347190-33-4 88%
Reaction Conditions:
Stage #1: 2-(3-bromoprop-2-yn-1-yl)-isoindoline-1,3-dionewith hydrogen fluoride;antimony pentafluoride at -40; for 0.166667 h;
Stage #2: with pyridine;hydrogen fluoride at -78; for 12 h;
References:
Cantet, Anne-Céline;Carreyre, Hélène;Gesson, Jean-Pierre;Renoux, Brigitte;Jouannetaud, Marie-Paule [Tetrahedron Letters,2006,vol. 47,# 31,p. 5547 - 5551]
