
2,2,2-TRIFLUORO-N-(2-(2-HYDROXYETHYLAMINO)ETHYL)ACETAMIDE synthesis
- Product Name:2,2,2-TRIFLUORO-N-(2-(2-HYDROXYETHYLAMINO)ETHYL)ACETAMIDE
- CAS Number:364056-54-2
- Molecular formula:C6H11F3N2O2
- Molecular Weight:200.16
Yield:364056-54-2 74.9%
Reaction Conditions:
in diethyl ether at 0 - 20; for 2 h;
Steps:
1.1 The first step: 2,2,2-trifluoro-N-(2-((2-hydroxyethyl)amino)ethyl)acetamide
At 0°C, 2-(2-aminoethylamine)ethanol (10.0g, 96.0mmol) was successively added to a 100mL round-bottom flask,The resulting mixture of dry ether (30 mL) and ethyl trifluoroacetate (13.6 g, 96.0 mmol) was stirred at room temperature for 2 h, and a white precipitate formed.Filtration, the filter cake was washed twice with ether (20mL×2), and dried to obtain 2,2,2-trifluoro-N-(2-((2-hydroxyethyl)amino)ethyl)acetamide (14.6g, white solid), yield: 74.9%.
References:
WO2022/117051,2022,A1 Location in patent:Page/Page column 57