(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate synthesis

1synthesis methods

Product Name:(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate
CAS Number:370880-79-8
Molecular formula:C18H24N2O4
Molecular Weight:332.39

1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(methylsulfonyl)oxy]methyl]-, phenylmethyl ester

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(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

370880-79-8
19 suppliers
$504.38/5MG

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 20 h
1.2: pH ~ 12
2.1: sodium hydroxide / ethanol; water / 1.5 h / 60 °C
3.1: sodium hydroxide / ethanol; water / 0.67 h / 20 °C

References:

WO2011/50200,2011,A1

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