1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester synthesis

2synthesis methods

Product Name:1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester
CAS Number:374795-42-3
Molecular formula:C14H25NO4
Molecular Weight:271.35

203662-51-5 Synthesis

4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester

203662-51-5
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1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester

374795-42-3
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 23 °C
2.1: Grubbs catalyst first generation / dichloromethane / 18 h / 0 - 23 °C
3.1: borane-THF / tetrahydrofuran / 18 h / 0 °C
3.2: 1 h / 0 - 23 °C

References:

Cernak, Timothy;Dykstra, Kevin;Levorse, Dorothy;Verras, Andreas;Balkovec, James;Nargund, Ravi;DeVita, Robert [Tetrahedron Letters,2011,vol. 52,# 48,p. 6457 - 6459]

79099-07-3 Synthesis

79099-07-3
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374795-42-3
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References