1''-BENZYL-3H-SPIRO[2-BENZOFURAN-1,4''-PIPERIDIN]-3-ONE synthesis
- Product Name:1''-BENZYL-3H-SPIRO[2-BENZOFURAN-1,4''-PIPERIDIN]-3-ONE
- CAS Number:37663-42-6
- Molecular formula:C19H19NO2
- Molecular Weight:293.36
Yield:37663-42-6 88%
Reaction Conditions:
Stage #1: N-phenyl benzoyl amidewith n-butyllithium in tetrahydrofuran at -78 - 0;Inert atmosphere;
Stage #2: 1-phenylmethyl-4-piperidone in tetrahydrofuran at 0 - 20;Inert atmosphere;
Stage #3: with hydrogenchloride in tetrahydrofuran;water;
References:
Trapella, Claudio;Fischetti, Carmela;Pela', Michela;Lazzari, Ilaria;Guerrini, Remo;Calo', Girolamo;Rizzi, Anna;Camarda, Valeria;Lambert, David G.;McDonald, John;Regoli, Domenico;Salvadori, Severo [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 14,p. 5080 - 5095] Location in patent:experimental part
3612-20-2
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![Spiro[isobenzofuran-1(3H),4'-piperidin]-3-ol, 1'-(phenylmethyl)-](/CAS/20210305/GIF/398476-51-2.gif)
398476-51-2
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37663-42-6
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3612-20-2
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$6.00/10g
37663-42-6
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