2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy- synthesis
- Product Name:2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-
- CAS Number:37682-06-7
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
85175-85-5
28 suppliers
$65.00/10mg
37682-06-7
26 suppliers
$284.57/250mg
Yield:37682-06-7 96%
Reaction Conditions:
with 10% Pd/C;hydrogen in acetic acid; under 3102.97 Torr; for 8 h;
Steps:
(d). 8-Methoxy-1,3,4,5-tetrahydrobenzo[d]azepine-2-one (3)
A solution of compound 2 (6.0 g, 31.7 mmol) in AcOH (100 mL) was hydrogenated over 10% Pd/C (600 mg) at 60 psi for 8 h. The catalyst was filtered off through a layer of Celite, and the filtrate was concentrated in vacuo. The crude product was triturated with Et2O to afford 3 (5.83 g, 96%) as a pale pink solid
References:
Wang, Min;Gao, Mingzhang;Steele, Brandon L.;Glick-Wilson, Barbara E.;Brown-Proctor, Clive;Shekhar, Anantha;Hutchins, Gary D.;Zheng, Qi-Huang [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 14,p. 4713 - 4718] Location in patent:experimental part
4133-34-0
278 suppliers
$15.00/1g
37682-06-7
26 suppliers
$284.57/250mg
1798-09-0
324 suppliers
$9.00/5g
37682-06-7
26 suppliers
$284.57/250mg
108962-85-2
16 suppliers
$175.00/100mg
37682-06-7
26 suppliers
$284.57/250mg
4133-34-0
278 suppliers
$15.00/1g
165530-13-2
1 suppliers
inquiry
37682-06-7
26 suppliers
$284.57/250mg