Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
38201-64-8

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE synthesis

4synthesis methods
361368-64-1 Synthesis
3-Thiophenecarboxylic acid, 2-[(aminothioxomethyl)amino]-4,5-dimethyl-, ethyl ester

361368-64-1
3 suppliers
inquiry

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

38201-64-8
19 suppliers
inquiry

-

Yield:38201-64-8 24%

Reaction Conditions:

Stage #1: ethyl 2-(aminothioxomethyl)amino-4,5-dimethyl-3-thiophenecarboxylatewith sodium hydroxide in ethanol at 20; for 0.25 h;Heating / reflux;
Stage #2: with acetic acid in ethanol;water at 20;

Steps:

50

To a suspension of ethyl 4,5-dimethyl-2-thioureidothiophene-3-carboxylate (Example 50a) (37 mg, 0.17 mmol) in dry EtOH (10 mL) was added sodium hydroxide (21 mg, 0.52 mmol). The reaction mixture was then stirred at room temperature for 5 minutes and refluxed for 10 minutes. The reaction mixture was cooled to room temperature, neutralized with 10% AcOH and then concentrated to dryness. The residue was purified by chromatography on silica gel (Gradient 0-50% EtOAc in Hexanes) to give the title compound (8 mg) in 24% yield. 1H NMR (400 MHz, DMSO-d6) δ 2.25 (s, 6H), 12.24 (s, 1H), 13.27 (s, 1H). MS 202 (MH+).

References:

US2008/306053,2008,A1 Location in patent:Page/Page column 67

2-amino-4,5-dimethyl-thiophene-3-carbonitrile

4651-94-9
87 suppliers
inquiry

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

38201-64-8
19 suppliers
inquiry

References
Potassium thiocyanate

333-20-0
458 suppliers
$13.50/100G

4815-24-1 Synthesis
ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE

4815-24-1
159 suppliers
$14.00/1g

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

38201-64-8
19 suppliers
inquiry

References
Thieno[2,3-d]pyrimidine-2(1H)-thione, 3,4-dihydro-4-imino-5,6-dimethyl-3-phenyl-

126105-79-1
0 suppliers
inquiry

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

38201-64-8
19 suppliers
inquiry

References

2-MERCAPTO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE Related Search:

2-MERCAPTO-3-PHENYL-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE (1)benzothieno(2,3-d)pyrimidin-4(1h)-one,2,3,5,6,7,8-hexahydro-3-methyl-2-thio