1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- synthesis
- Product Name:1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)-
- CAS Number:390367-50-7
- Molecular formula:C15H15N3O5
- Molecular Weight:317.3
![Carbamic acid, N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]ethyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/390367-45-0.gif)
390367-45-0
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390367-50-7
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Yield:390367-50-7 86%
Reaction Conditions:
with trifluoroacetic acid at 50; for 3 h;
Steps:
25 4-(2-Aminoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
tert-Butyl (2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethyl)carbamate (152 mg, 0.37 mmol) was dissolved in TFA (3.7 mL, 0.1 M) and heated to 50 °C for 3 hours. The mixture was cooled to room temperature, diluted with methanol and concentrated under reduced pressure. The material was purified by column chromatography (ISCO, 4 g silica column, 0-20% 1.75N H3 MeOH/DCM) to give the free base product (101 mg, 86%).LCMS 317 (M+H)+.
References:
WO2019/79701,2019,A1 Location in patent:Paragraph 0363; 0372; 0373; 0374
5054-59-1
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2650-64-8
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90802-45-2
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