ChemicalBook CAS DataBase List 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE synthesis

6synthesis methods

Product Name:5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE
CAS Number:398491-59-3
Molecular formula:C10H16N4O2
Molecular Weight:224.26

175463-32-8

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE

398491-59-3

The general procedure for the synthesis of 3-amino-5-tert-butoxycarbonyl-pyrrolo[3,4-C]pyrazole from 1-Boc-3-cyano-4-pyrrolidinone was as follows: 1-Boc-3-cyano-4-pyrrolidinone (4.5 g, 43 mmol) was dissolved in anhydrous ethanol (250 ml), and the reaction was stirred for 3 h at 60 °C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Saturated sodium bicarbonate solution (50 ml) was added to the residue until the solid was completely dissolved. Subsequently, the extracted organic phase was removed by evaporation under reduced pressure to give the white solid product 1b (6.3 g, 66% yield). The product did not require further purification and could be used directly in the next step of the reaction.

175463-32-8 Synthesis

175463-32-8
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$6.00/1g

398491-59-3
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$45.00/10mg

Yield: 66%

Reaction Conditions:

with hydrazine in ethanol at 60; for 3 h;

Steps:

1.1 Step 1: Preparation of intermediate 1b
(4.5 g, 43 mmol) was dissolved in absolute ethanol (250 ml) and stirred at 60 ° C for 3 h. The solvent was distilled off under reduced pressure and saturated sodium bicarbonate solution (50 ml) was added to a solid completely dissolved,The extracted organic phase was removed by evaporation under reduced pressure to give the white solid Ib (6.3 g, yield 66%) which was used in the next step without further purification.

References:

Beijing Ruichuang Zhiyuan Biological Technology Co., Ltd.;Qiao Dehua CN106279177, 2017, A Location in patent:Paragraph 0103; 0104; 0105