(3R)-1-methylpiperidine-3-carboxylic acid synthesis
- Product Name:(3R)-1-methylpiperidine-3-carboxylic acid
- CAS Number:952480-19-2
- Molecular formula:C7H13NO2
- Molecular Weight:143.18
205194-12-3
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952480-19-2
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Yield:952480-19-2 99.1%
Reaction Conditions:
with water;sodium hydroxide at 25; for 1 h;
Steps:
4.1.14. (R)-1-Methylpiperidine-3-carboxylic acid (10e)
Sodium hydroxide (0.14 g, 3.60 mmol) was dissolved in H2O(4 mL) and then added dropwise into 9e (0.20 g, 1.20 mmol). Thereactionwas stirred for 1 h at 25 C. The mixturewas acidified to pH2 with 1 N HCl and stirred for 0.5 h at 0 C. After this period, thereaction mixture was washed with petroleum ether and concentratedunder reduced pressure. The solid was dissolved with anhydrous methanol, filtered through Celite 545 and concentratedto afford 10e in the form of a white powder: yield 0.17 g(99.1%); 1H NMR (500 MHz, CD3OD) d 3.75e3.66 (m, 1H), 3.53e3.38(m, 1H), 3.21e3.00 (m, 2H), 2.90 (s, 3H), 2.26e2.13 (m, 1H),2.08e2.00 (m, 1H), 1.95e1.71 (m, 2H), 1.63e1.52 (m, 1H); LC-MS(ESI) [M H]- m/z 142.4.
References:
Zhu, Mei;Zhou, Huiyu;Ma, Ling;Dong, Biao;Zhou, Jinming;Zhang, Guoning;Wang, Minghua;Wang, Juxian;Cen, Shan;Wang, Yucheng [European Journal of Medicinal Chemistry,2021,vol. 220,art. no. 113450]
25137-01-3
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952480-19-2
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