4-(1,1-Dimethoxyethyl)-2-(methylthio)pyrimidine synthesis
- Product Name:4-(1,1-Dimethoxyethyl)-2-(methylthio)pyrimidine
- CAS Number:521092-35-3
- Molecular formula:C9H14N2O2S
- Molecular Weight:214.28
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Yield:-
Reaction Conditions:
Stage #1: 1-(N,N-dimethylamino)-4,4-dimethoxypent-1-en-3-one;thioureawith sodium methylate in methanol at 70; for 3 h;
Stage #2: methyl iodide in methanol at 0 - 20; for 1 h;
Steps:
3.2
(2) In 800 ml of methanol was dissolved 141 g of the compound obtained in (1), and after adding 114 g of thiourea and 292 g of 28% sodium methoxide-methanol, the mixture was stirred at 70°C for 3 hours.. The mixture was ice-cooled, and after adding 215 g of methyl iodide drowise, the mixture was stirred at room temperature for an hour.. After concentration of the reaction mixture, water was added to the mixture and the resulting mixture was extracted with ethyl acetate.. The organic layer was washed, dried and concentrated to give 142 g of 4-(1,1-dimethoxyethyl)-2-methylsulfanylpyrimidine.
References:
EP1439174,2004,A1 Location in patent:Page 89
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