4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL synthesis
- Product Name:4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL
- CAS Number:223251-25-0
- Molecular formula:C15H23Cl2NO
- Molecular Weight:304.26
223251-16-9
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$19.00/250mg
223251-25-0
171 suppliers
$10.00/1g
Yield: 90%
Reaction Conditions:
with thionyl chloride in tetrahydrofuran at 0 - 55; for 6 h;
Steps:
3.4
S4: 561 g of 4- (2-Hexamethyleneimino-1-) ethoxy) Benzyl alcohol obtained from S3 is added into 1.2 liter of tetrahydrofuran, cooled at 0 ° C, added the drops of 320 g of thionyl chloride, after that temperature is gradually raised at 55 ° C for 6 hours, about 600 ml of the solvent is distilled off, 300 ml of ethyl acetate is added to the residue, the mixture is cooled at 0 ° C and stirred for 30 minutes, filtered, washed with 300 ml of ethyl acetate, dry, and then obtained 619 g of 1- (2- (4- (chloro methyl) phenoxyl) ethyl) azacycloheptane hydrochloride, yield 90% and measured HPLC purity 99%.
References:
Jinan Mei Gao Bio-pharmaceutical Technology Co., Ltd.;Xiao Tong;Dong Yuehui;Chen Maoying;Kou Zengjie CN107400087, 2017, A Location in patent:Paragraph 0045
![BenzeneMethanol, 4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]- (hydrochloride)](/CAS/20150408/GIF/328933-65-9.gif)
328933-65-9
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$79.00/100mg
223251-25-0
171 suppliers
$10.00/1g
623-05-2
696 suppliers
$5.00/100mg
223251-25-0
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$10.00/1g
26487-67-2
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$6.00/1g
223251-25-0
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$10.00/1g
2205-31-4
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$45.00/50mg
223251-25-0
171 suppliers
$10.00/1g