4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE synthesis
- Product Name:4-(2,4-DIFLUOROPHENYL)-3-THIOSEMICARBAZIDE
- CAS Number:206559-58-2
- Molecular formula:C7H7F2N3S
- Molecular Weight:203.21
141106-52-7
141 suppliers
$21.00/1g
206559-58-2
34 suppliers
$23.00/250mg
Yield:206559-58-2 83.7%
Reaction Conditions:
with hydrazine hydrate in ethanol at 80; for 6 h;
Steps:
2.1 (1) Synthesis of intermediate 4-(2,4-difluorophenyl)thiosemicarbazide
Add 2,4-difluorophenylisothiocyanate (1.71g, 0.01mol), 30ml ethanol, 85% hydrazine hydrate (1.17g, 0.02mol) into a 50mL dry single-necked flask, and heat to 80 under stirring , React for 6 hours, TLC detects that the reaction has ended, stop the reaction. The reaction solution was cooled to room temperature, filtered with suction, and the filter cake was washed with ethanol, and dried to obtain 1.70 g of the white solid product 4-(2,4-difluorophenyl)thiosemicarbazide with a yield of 83.7%.
References:
CN112679409,2021,A Location in patent:Paragraph 0051-0058
367-25-9
486 suppliers
$5.00/5g
206559-58-2
34 suppliers
$23.00/250mg