4-(2,4-Difluorophenyl)benzaldehyde synthesis

Yield:-

Reaction Conditions:

Suzuki Coupling;

Steps:

1-Phosphono-4-[4-(2,4-difluorophenyl)phenyl]butylsulfonic acid tripotassium salt, 10. 4-(2,4-difluorophenyl)benzaldehyde was made by a Suzuki coupling reaction from 2,4-difluorophenylboronic acid (3.6 mmol) and 4-bromobenzaldehyde (3 mmol), as described previously (21). Compound 10 was prepared from the aldehyde thus obtained, following general method F, as a white powder (470 mg, 28% overall yield). Anal. (C₁₆H₁₄F₂K₃O₆PS) C, H; ¹H NMR (400 MHz, D₂O): δ 1.65-2.00 (m, 4H, -CH₂CH₂-); 2.45-2.60 (m, 2H, PhCH₂), 2.80-2.85 (m, 1H, CHSO₃K), 6.80-7.40 (m, 7H, aromatic); ³¹P NMR (D₂O): δ 12.5.

References:

US2012/22024,2012,A1 Location in patent:Page/Page column 30