4-(2-Ethoxyvinyl)benzonitrile synthesis
1synthesis methods
- Product Name:4-(2-Ethoxyvinyl)benzonitrile
- CAS Number:1082604-62-3
- Molecular formula:C11H11NO
- Molecular Weight:173.2111
Yield:-
Reaction Conditions:
Stage #1: 1-ethoxyacetylenewith borane-THF in tetrahydrofuran at 20; for 2 h;
Stage #2: 4-iodobenzonitrilewith sodium hydroxide;palladium diacetate;triphenylphosphine in tetrahydrofuran; for 18 h;Reflux;
References:
Bouloc, Nathalie;Large, Jonathan M.;Smiljanic, Ela;Whalley, David;Ansell, Keith H.;Edlin, Christopher D.;Bryans, Justin S. [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 19,p. 5294 - 5298] Location in patent:scheme or table