4-(2-FURYL)-1,3-THIAZOL-2-AMINE synthesis
- Product Name:4-(2-FURYL)-1,3-THIAZOL-2-AMINE
- CAS Number:28989-52-8
- Molecular formula:C7H6N2OS
- Molecular Weight:166.2
1192-62-7
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Yield:28989-52-8 85%
Reaction Conditions:
with carbon tetrabromide;triethylamine in acetonitrile at 20; for 3 h;
Steps:
General procedure for the synthesis of 2-aminothiazoles 3
General procedure: To a mixture of ketone (0.5 mmol), thiourea (0.5 mmol), and triethylamine (0.5 mmol) in acetonitrile (3 mL) was added carbon tetrabromide (0.5 mmol) in a round bottom flask at room temperature and the reaction mixture was stirred for 2-6 h. After completion of the reaction (monitored by TLC), water (5 mL) was added and the mixture was extracted with EtOAc (3*5 mL). The combined organic phase was dried over MgSO4, filtered, and evaporated under reduced pressure to give the crude product. The resulting product was purified by silica gel column chromatography using a gradient mixture of hexane/ethyl acetate as eluent to afford an analytically pure sample of 3.
References:
Keshari, Twinkle;Kapoorr, Ritu;Yadav, Lal Dhar S. [Tetrahedron Letters,2015,vol. 56,# 41,p. 5623 - 5627] Location in patent:supporting information
13331-23-2
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502145-18-8
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28989-52-8
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15109-94-1
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28989-52-8
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527-69-5
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28989-52-8
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$45.00/100mg