4-(3,3,3-trifluoropropyl)aniline synthesis
- Product Name:4-(3,3,3-trifluoropropyl)aniline
- CAS Number:1236410-18-6
- Molecular formula:C9H10F3N
- Molecular Weight:189.18
![Benzene, 1-nitro-4-[(1E)-3,3,3-trifluoro-1-propen-1-yl]-](/CAS/20210305/GIF/78622-57-8.gif)
78622-57-8
0 suppliers
inquiry
1236410-18-6
7 suppliers
inquiry
Yield:1236410-18-6 47%
Reaction Conditions:
with hydrogen;20 % Pd(OH)2/C in ethanol;ethyl acetate at 20; under 2585.81 Torr; for 20 h;Inert atmosphere;
Steps:
(E)-1-nitro-4-(3,3,3-trifluoroprop-1-enyl)benzene (510 mg, 2.35 mmol) was dissolved in ethanol (15 mL) and ethyl acetate (15 mL). 20% Palladium hydroxide on carbon (250 mg) was carefully added to reaction vessel under a steady stream of nitrogen. The reaction was stirred in a parr shaker at room temperature under hydrogen (50 PSI) for 20 hours. The reaction mixture was filtered through a pad of celite and filtrate concentrated. Crude oil was purified on silica gel, eluding with a gradient from 5% to 40% ethyl acetate in heptane to give 4-(3,3,3-trifluoropropyl)benzenamine (210 mg, 47%). GCMS was 189 at 1.35 min. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 2.22-2.42 (m, 2H) 2.68-2.80 (m, 2H) 3.57 (br. s., 2H) 6.59-6.66 (m, 2H) 6.91-7.01 (m, 2H)
References:
US2010/197591,2010,A1 Location in patent:Page/Page column 44
1236764-22-9
0 suppliers
inquiry
1236410-18-6
7 suppliers
inquiry
555-16-8
563 suppliers
$5.00/5g
1236410-18-6
7 suppliers
inquiry
16642-79-8
175 suppliers
$14.14/1gm:
1236410-18-6
7 suppliers
inquiry