4-(3-allylthioureido)benzoic acid synthesis
- Product Name:4-(3-allylthioureido)benzoic acid
- CAS Number:1142-29-6
- Molecular formula:C11H12N2O2S
- Molecular Weight:236.29
Yield:1142-29-6 59%
Reaction Conditions:
in ethanol at 20 - 60;
Steps:
Allyl thioureas (4a-4e) (general procedure).
General procedure: Allyl isothiocyanate (1 mmol) was added drop wise to ethanolic solution of an appropriate amine (1 mmol) upon stirring. The reaction mixture was heated at 50-60 °C for 3.5-4 h followed by stirring at room temperature for 24 h. The reaction mixture was filtered off to give the corresponding thiourea that was crystallized from either ethanol or glacial acetic acid. 1-Allyl-3-phenylthiourea (4a).
References:
Khare;Sharma;Sharma [Russian Journal of General Chemistry,2016,vol. 86,# 3,p. 702 - 707][Zh. Obshch. Khim.,2016,vol. 86,# 3,p. 702 - 707,6]
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