4,4,4-TRIFLUORO-3-HYDROXYBUTYRAMIDE synthesis

Yield:453-34-9 87.9%

Reaction Conditions:

with ammonium thiocyanate in methanol at 20;

Steps:

2-42.1 Step 1: synthesis of 4,4,4-trifluoro-3-hydroxybutanamide

A solution of ethyl 4,4,4-trifluoro-3-hydroxybutanoate (3.0 g, 16.1 mmol) in MeOH (8 mL) was stirred with aqueous ammonium (16 mL) at room temperature overnight. The mixture was concentrated to afford 4,4,4-trifluoro-3-hydroxybutanamide (2.19 g, yield: 87.6%).

References:

US2016/200741,2016,A1 Location in patent:Paragraph 0467-0468