4-(4-BROMOPHENOXY)ANILINE synthesis
- Product Name:4-(4-BROMOPHENOXY)ANILINE
- CAS Number:31465-35-7
- Molecular formula:C12H10BrNO
- Molecular Weight:264.12
21969-04-0
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31465-35-7
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Yield:31465-35-7 87%
Reaction Conditions:
Stage #1: 1-(4-nitrophenoxy)-4-bromobenzenewith hydrazine hydrate in ethanol at 28 - 30; for 0.166667 h;
Stage #2: in ethanol;water at 50 - 60;
Steps:
Synthesis of compounds (3a-d)
General procedure: A mixture of 1-substituted-4-nitrobenzene (9.3mmol) and N2H4*H2O (27.9 mmol) in 20 ml ethanol was stirred for 10 min at 28-30 °C. The suspension of Raney-Ni in water (0.02 g, 4.41 ml) was added by stirring in three portions at 10 minute intervals. After 30 min, when reaction had subsided, stirring was continued for further 6 h at 50-60 °C. The catalyst was removed by filtration. The solvent was evaporated to obtain compounds 6-10:
References:
Antipin, Roman L.;Beshnova, Daria A.;Petrov, Rostislav A.;Shiryaeva, Anna S.;Andreeva, Irina P.;Grigorenko, Vitaly G.;Rubtsova, Maya Yu.;Majouga, Alexander G.;Lamzin, Victor S.;Egorov, Alexey M. [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 7,p. 1588 - 1592] Location in patent:supporting information
350-46-9
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106-41-2
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101-84-8
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620-88-2
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31465-35-7
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