4-(4-BROMOPHENYL)-2(3H)-THIAZOLONE HYDRAZONE synthesis
- Product Name:4-(4-BROMOPHENYL)-2(3H)-THIAZOLONE HYDRAZONE
- CAS Number:4871-22-1
- Molecular formula:C9H8BrN3S
- Molecular Weight:270.15
Yield:4871-22-1 87%
Reaction Conditions:
at 78; for 17 h;
Steps:
4-6 Synthesis method:
Put 2,4'-dibromoacetophenone (2.78g, 10mmol) and thiosemicarbazide (0.91g, 10mmol) in a round bottom flask, add absolute ethanol (35mL) and raise the temperature to 78°C, The reaction was refluxed for 17 hours.After the completion of the reaction was detected by a high performance liquid chromatography-mass spectrometer, the reaction was terminated, and the compound in Example 5 was separated.Example 5Separation and purification of 4-(4-bromophenyl)-2-hydrazino-1,3-thiazoleAfter the reaction in Example 4 was completed, the flask was placed in an ice bath and stirred for 30 minutes to allow the solid to be fully analyzed, and then filtered under reduced pressure to remove the ethanol. The solid was collected and washed with distilled water and methanol to obtain 1.82g of yellow solid product, which is the compound II, the yield is 67%.
References:
CN112898227,2021,A Location in patent:Paragraph 0038-0050
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