(4,4-difluoropiperidin-3-yl)Methanol hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;dichloromethane at 20; for 2 h;

Steps:

39

A mixture of 4,4-difluoro-3-methoxymethoxymethyl-piperidine-1-carboxylic acid tert-butyl ester (2.0 mmol, 0.6g) and 4M HCI in dioxane solution (2 ml_) in 10 ml_ of DCM was stirred at room temperature for 2 h. Removal of the solvent afforded the crude (4,4-difluoro-piperidin-3-yl)-methanol hydrochloride salt (360 mg, 98%), which was used directly in the next step

References:

WO2011/103091,2011,A1 Location in patent:Page/Page column 95