4-(4-METHOXY-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE synthesis
- Product Name:4-(4-METHOXY-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
- CAS Number:105512-88-7
- Molecular formula:C11H12N2OS
- Molecular Weight:220.29
Yield:105512-88-7 78%
Reaction Conditions:
with iodine for 8 h;Heating;
Steps:
Synthesis of 2-amino-4-(4'-substituted phenyl)-5-methyl-1,3-thiazole (4a-f):
General procedure: Thiourea (0.04 mol) and iodine (0.02 mol)were triturated and mixed with appropriate 4-substituted propiophenone (0.02 mol), the mixture was heated on a water bathat 70 °C with occasional stirring for 8 h. The solid product was triturated and mixed with ethyl ether to remove unreacted 4-substituted phenyl propiophenone, washed with aqueous thiosulphate (5 %) to remove excess iodine and finally with water. The crude product was dissolved in hot water, filtered toremove impurity and 2-amino-4-(4'-substituted phenyl)-5-methyl-1,3-thiazole (Scheme-II) was precipitated by additionof ammonia solution. The product was recrystallized from ethanol to give crystal of desired product [9].
References:
Maher [Asian Journal of Chemistry,2017,vol. 29,# 12,p. 2794 - 2798]
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