4,5,6-trichloro-2-methylpyrimidine synthesis

Yield:1780-28-5 82 %

Reaction Conditions:

with trichlorophosphate at 105;Time;

Steps:

1; 2; 3 Example 1

The specific implementation process is as follows: 20.5g (0.1mol) of 2-methyl-5-bromo-4,6-dihydroxypyrimidine was added to a 500mL four-port reactor, and 153.3g (1mol) of phosphorus oxychloride was added at room temperature, and the return device was connected to the tail gas alkali absorption device. Heat toreflux(internal temperature 105 °C) with an oil bath for 16h. The reaction solution was cooled to room temperature, and then added to 1000mL of ice water, stirred until phosphorus oxychloride was all dissolved, at this time a large number of white solids appeared in the aqueous solution, filtered, white solids were vacuum dried at room temperature, and the product was obtained 16.15g, the content was 97.2%, and the yield was 82%.

References:

CN115490641,2022,A Location in patent:Paragraph 0018-0033