4-(5-AMINO-[1,3,4]THIADIAZOL-2-YL)-PHENOL synthesis
- Product Name:4-(5-AMINO-[1,3,4]THIADIAZOL-2-YL)-PHENOL
- CAS Number:59565-53-6
- Molecular formula:C8H7N3OS
- Molecular Weight:193.23
123-08-0
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$5.00/10g
79-19-6
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$14.00/1g
59565-53-6
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$130.00/50mg
Yield:59565-53-6 80%
Reaction Conditions:
with tert.-butylhydroperoxide in ethanol;water at 20; for 4 h;Green chemistry;
Steps:
General procedure for the preparation of 2-amino-1,3,4-thiadiazoles
General procedure: A mixture of aldehydes (1 mmol), thiosemicarbazide (1 mmol) in ethanol (10 mL) and tert-butyl hydroperoxide (TBHP, 70% aqueous solution) (1 mmol) was stirred at room temperature for 4h. The progress of the reaction was monitored by TLC using hexane/ EtOAc as the mobile phase. After the completion of the reaction, ethanol was evaporated under vacuum to obtain a solid residue. To this solid residue, ethyl acetate (10 ml) and water (10 ml) were added followed by saturated sodium bicarbonate solution (10 mL). Separated organic layer was dried over anhydrous sodium sulfate and evaporated under vacuum to obtain the product, which was further purified using silica gel column chromatography (hexane/ethyl acetate).
References:
Hatvate, Navnath T.;Ghodse, Shrikant M.;Telvekar, Vikas N. [Synthetic Communications,2018,vol. 48,# 3,p. 285 - 290] Location in patent:supporting information
5339-74-2
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$28.60/25MG
59565-53-6
19 suppliers
$130.00/50mg
79-19-6
508 suppliers
$14.00/1g
99-96-7
813 suppliers
$5.00/10g
59565-53-6
19 suppliers
$130.00/50mg
947527-72-2
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59565-53-6
19 suppliers
$130.00/50mg
123-08-0
952 suppliers
$5.00/10g
59565-53-6
19 suppliers
$130.00/50mg